Environmental Pathology: SY09-2
Multiple sclerosis (MS) and neurodegeneration: cause and pathogenesis in relation to electromagnetic fields (EMF)
Multiple sclerosis (MS) is prevalent in higher latitude areas where geomagnetic storms often occur. The earliest pathological finding is myelin destruction. Myelin is a high capacitance electrolytic capacitor that can store a large amount of charge and energy. Since storms possess high-energy electromagnetic fields (EMF), the capacitor will be overcharged, which may break down the dielectric. As a result, a short circuit occurs and electrolytes heat up and/or the capacitor may burst. Also, EMFs have the potential to induce hotspots in the center of the brain. The increased temperature of the cerebrospinal fluid will cause hot water burns in surrounding areas. Thus, two distinct lesions exist in MS, electric shock and hot water burns. In addition, the overcharged capacitor will produce repetitive or continuous action potentials, causing excess Ca2+ influxes and subsequent excitotoxicity. This leads to mitochondrial dysfunction, including an energy deficit, oxidative stress and apoptosis. Moreover, EMFs activate microglia via activation of voltage-gated ion channels. These MS related neurodegenerative and inflammatory processes could have causes and pathogeneses in common with Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis, which are often reported in MS patients. I hypothesize thus that MS and certain common neurodegenerative diseases are caused by high energy EMF.
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